Cooperative Biological Engagement Program (CBEP)

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  1. Training (Estambale, Oyugi)


One of the goals of Cooperative Biological Engagement Program (CBEP) is to provide education and training to enhance clinical, laboratory and epidemiological safety and security with regard to especially dangerous pathogens. To this end, we propose to develop and conduct short courses, internships and advanced training to healthcares workers, border security officers and workers in institutions that are likely to encounter or involved in work with hemorrhagic fever viruses.


  1. To develop and conduct short courses in disease outbreak, surveillance, biosecurity, biosafety and response for health workers in Kenya.
  2. To develop and conduct Postgraduate training biosecurity, bioethics, disaster preparedness and response.



Short courses in disease outbreak, surveillance, biosecurity, biosafety and response: The recent outbreak of Ebola hemorrhagic fever in Uganda has clearly shown that there is need to train Kenyan healthcare workers on early disease detection, outbreak and response. Cases of infections unrelated to Ebola in Kenya being reported as Ebola were mainly due to lack of knowledge in epidemiology of Ebola virus among healthcare workers in Kenya. Additionally, Kenya has witnessed sporadic outbreaks of heamorrhagic fever viruses ranging from Rift valley fever virus, yellow fever virus, murburg virus over the last few decades. While the magnitude of such outbreaks vary depending on which virus is causing the outbreak, it is very difficult to predict when the next outbreak will occur and with what magnitude. The sporadic outbreak of these viruses and the impact they have on the lives of human and livestock implies the need to prepare and respond promply whenever, such outbreaks occur. It is due these gaps that we propose to train Kenyan healthcare workers on disaster preparedness and response, biosecurity and surveillance of hemorrhagic fever viruses to healthcare workers in Kenya.

We will target to train doctors, nurses, laboratory technicians and scientists from ministry health or public health and institutions of higher learning involved in the training of healthcare workers. The training will target those at management level and middle level cadres of staff. The management level cadres will include heads of health centre, district and provincial hospitals across the country. This group is important when it come to policy formulation and implementation and therefore will play a big role in the implementation of the training. 


Deliverables and outcome:


Postgraduate training on biosecurity, bioethics, disaster preparedness and response:

Deliverables and outcomes:


Reviewer’s comments

  1. The full proposal requires a detailed work plan describing how the tasks will be accomplished and must include more specific information on the number of samples, sample type, collection method, storage and destruction processes, sample sequencing and analysis, and the proposed deliverables and outcomes.
  2. Greater attention should be placed into in-country collaboration and working with another Kenyan biological research organization with experience in CCHFV, RVFV, Ebola, and/or Marburg virus research.
  3. Further, the full proposal should address the level and type of training that should be administered to Kenyan scientists and technicians to provide sustainability and increase capacity.  Tying into the issue of training is a large concern for needed BSL-4 laboratory space and adequately trained technicians.
  4. The proposer should discuss whether or not the samples would contain inactivated select agents or if the samples would contain live pathogens and require a greater level of skilled personnel, dedicated facilities, training programs, and partner country support and expertise.
  5. If more work can be performed in Kenya, that is preferred over having the US analyze sample because finding an in-country solution would enhance capability and sustainability.


Evaluation points

Evaluation Factor 1: Technical/Scientific Merit – This area addresses the technical approach and the contribution of research to advancing CBEP objectives.  It evaluates what activities will be performed, skills required, and/or how it will be accomplished. 

Evaluation Factor 2: Expected Benefit to CBEP – This area addresses the extent to which the proposed research supports CBEP objectives.  It also considers the derivative benefit that may be realized by the performer and its organization through performance of the proposed effort.

Evaluation Factor 3: Program Capabilities – This factor addresses the facilities, equipment, personnel and host country support of the proposed research.

Evaluation Factor 4: Cost and Schedule – This factor considers the adequacy and reasonableness of funding and timeline associated with the proposed research.  It includes labor (in terms of time and mix), equipment, other direct costs, fee (if applicable), and indirect costs.  Metrics that evaluate project timelines and accomplishment of milestones by expected dates will also be considered.

Evaluation Factor 5: Dual-Use Potential –This factor evaluates whether the proposed effort contains research that, based on current understanding, can reasonably be anticipated to provide knowledge, information, products, or technologies that could be directly misapplied to pose a significant threat with broad potential consequences to public health and safety, agricultural crops and plants, animals, the environment, materiel, or national security.  Research involving select agents and toxins is within scope of the CBEP mission; however, the use of specific select agents and toxins in certain categories of experiments is considered dual-use research of concern (DURC) [1]Proposals that contain DURC will not be selected or funded.